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ALPHA KARYOPHERINS
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DeCS
Descriptor
English
:
alpha Karyopherins
Descriptor
Spanish
:
alfa Carioferinas
Descriptor
Portuguese
:
alfa Carioferinas
Tree Number:
D12.776.157.530.750.500.100
D12.776.543.585.750.500.100
D12.776.660.502.100
Definition
English
:
Nucleocytoplasmic transport molecules that bind to the
NUCLEAR LOCALIZATION SIGNALS
of cytoplasmic molecules destined to be imported into the
CELL NUCLEUS
. Once attached to their cargo they bind to
BETA KARYOPHERINS
and are transported through the
NUCLEAR PORE
COMPLEX. Inside the
CELL NUCLEUS
alpha karyopherins
dissociate from beta karypherins and their cargo. They then form a complex with
CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN
and
RAN GTP-BINDING PROTEIN
which is exported to the
CYTOPLASM.
See Related
English
:
Nuclear Localization Signals
History Note
English
:
2002; use ALPHA KARYOPHERINS (NM) 1994-2001; for IMPORTIN-ALPHA use KARYOPHERINS 1995-2001; for NLS-BINDING PROTEIN, NLSBP & NUCLEAR LOCALIZATION SIGNAL-BINDING PROTEIN use NOPP140 (NM) 1992-2001
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
36192
Unique Identifier:
D028901
Occurrence in VHL
:
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